Histomorphological study of salivary gland neoplasms: fifteen year study

Background: The neoplasms of salivary glands are relatively uncommon and represent less than 2% of all human tumors. They are morphologically diverse, with marked heterogeneity among the different subtypes and even within the same tumor. The unpredictability in the long term outcome imposes a significant challenge in the clinical management.Methods: This is a descriptive study done in a tertiary care teaching hospital over a period of 15 years. Patient details were collected from medical case records. All specimens were evaluated for site, laterality, size, nature of the cut surface and intactness of the capsule. Two to 5 representative bits were taken from each specimen and subjected to routine fixation, processing and section cutting followed by Haematoxylin and Eosin staining.Results: A total of 138 salivary gland tumors were diagnosed from patients in the age group of 13 to 90 years with a mean age of 41.8 years. There were 53 (38.4%) males and 85 (61.6%) females with male to female ratio of 1:1.42. There were 115 (83.3%) benign tumors and 23 (16.7%) malignant tumors. Pleomorphic adenoma accounted for 70.3% of all salivary gland tumors followed by mucoepidermoid carcinoma (10.9%), Warthin tumor (8%), basal cell adenoma (2.9%), adenoid cystic carcinoma (2.2%), squamous cell carcinoma (2.2%), myoepithelioma (1.4%), oxyphillic adenoma (0.7%), acinic cell carcinoma (0.7%) and salivary duct carcinoma (0.7%).Conclusions: The salivary gland neoplasms are relatively uncommon head and neck tumors. Parotid gland is the commonest site of occurrence. Pleomorphic adenoma is the commonest benign and mucoepidermoid carcinoma the commonest malignant salivary gland tumor.

Diagnostic and prognostic implications of MAML2 gene translocation in primary pulmonary mucoepidermoid carcinoma / 中华病理学杂志

Objective@#To investigate MAML2 gene-translocation in primary pulmonary mucoepidermoid carcinoma (PMEC) and pulmanary adenosquamous carcinoma, and the optimal diagnostic immunohistiochemical (IHC) panel in distinguishing PMEC from adenosqumous carcinoma.@*Methods@#Twenty-four cases of PMEC and 44 adenosqumous carcinoma diagnosed in the Guangdong General Hospital were tested for MAML2 translocation by fluorescent in-situ hybridization (FISH) using tissue array. An IHC panel including TTF1, Napsin A, CK5/6, p63, p40 and Ki-67 was performed on the cohort. The clinical data for all cases were collected and all PMEC patients had follow-up information.@*Results@#The patients′ age ranged form 6 to 73 years, with a median age of 32 years. The male to female ratio was 1.4∶1.0. MAML2 translocation was found in 16/24 (66.7%) cases of PMEC whereas all 44 cases adenosqumous carcinoma were negative for translocation. All the cases of the PMEC were negative for TTF1 and Napsin A but positive for CK5/6, p63 and p40 in the intermediate cells and epidermal-like cells. In most PMEC cases, the Ki-67 expression index was lower than 10%. In contrast, most cases of adenosqumous carcinomas expressed TTF1 and Napsin A in the adenomatous component and CK5/6, p63 and p40 in the squamous component, which expression pattern was different from that of PMEC. Based on IHC staining, 2 cases of highly invasive ALK-positive adenocarcinoma mimicing PMEC were also found in the study.@*Conclusions@#MAML2 gene translocation can be detected in about two-third of PMEC. Translocation of MAML2 gene and lower morphology grading are associated with good prognosis. The combined use of IHC antibodies panel is helpful to distinguish PMEC from the adenosqumous carcinoma and adenocarcinoma mimicing PMEC.

Mucoepidermoid carcinoma of the salivary glands: a retrospective study of 51 cases and review of the literature / Carcinoma mucoepidermoide de glándulas salivales. estudio retrospectivo de 51 casos y revisión de la literatura

The aim of this study is to present the casuistic of mucoepidermoid carcinoma of salivary glands in patients diagnosed at “Dr. Eduardo Cáceres Graziani” National Institute for Neoplastic Diseases, Lima, Perú. From January 2002 to December 2012, 51 cases were diagnosed as mucoepidermoid carcinoma. The number of female patients was higher, with 28 cases (54.9%), and regarding age distribution, 33.3% of the patients were under 30 years old. Pain was one of the main symptoms, and 74.5% of the mucoepidermoid carcinomas were located in the parotid gland. It is concluded that epidemiology regarding age and gender of the 51 cases analyzed was in the same range as other studies, and that most cases were located in major salivary glands, in agreement with reports on other populations. Other characte ristics showed a homogeneous distribution.

El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el Instituto Nacional de Enfermedades Neoplásicas “Dr. Eduardo Cáceres Graziani” Lima, Perú, desde el 2002 hasta el 2012. Realizamos un estudio retrospectivo en el cual fueron incluidos sujetos con diagnóstico primario de carcinoma mucoepidermoide en glándulas salivales. Entre enero de 2002 y diciembre de 2012, se registraron 51 casos. El número de pacientes de sexo femenino fue mayor, con 28 casos (54,9%) y con respecto a la distribución por edades, el 33,3% de los pacientes eran menores de 30 años de edad. El dolor fue uno de los síntomas principales. El 74,5% de los carcinomas mucoepidermoides se localizaron en la glándula parótida. De los hallazgos obtenidos se concluye principalmente que en lo que respecta a la distribución epidemiológica de edad y género de los 51 casos analizados estas variaron en el mismo rango de otros estudios. También se distingue que el mayor número de casos estuvieron localizados en glándulas salivales mayores, dato en concordancia con otras poblaciones reporta das. Las demás características presentaron una distribución homogénea.

Study of Salivary Gland Neoplasms.

Tumors of the salivary glands are uncommon and they present a great variety of histological types with many structural variation. They have a low incidence and their anatomical relationship especially that of the parotid gland to the facial nerve make their management challenging. The present study was carried out to find out the prevalence of salivary gland neoplasms, to see associated conditions like sialadenitis, sialolithiasis coexisting with salivary gland neoplasms and to do cytohistopathological correlation. Total 96 cases were collected of which 66.7% were benign and 33.3% were malignant. In 81 (84.3%) cases tumors occurred in major salivary gland while 15 (15.6%) cases in minor salivary gland. Among major salivary gland, parotid was the commonest site and in minor salivary glands, palate was the commonest site followed by lips. Pleomorphic adenoma was the commonest benign tumor and adenoid cystic carcinoma was the commonest malignant tumor followed by mucoepidermoid tumor. There was one case of synovial sarcoma. Associated pathology like sialadenitis and sialolithiasis were present in 16 benign and 5 malignant tumors. Cytohistocorrelation was seen in 63 out of 64 (98.4%) benign and 16 out of 18 (88.8%) malignant tumors.

Therapeutic effect and prognostic factors for patients with mucoepidermoid carcinoma of parotid gland / 国际肿瘤学杂志

Objective To study the therapeutic effect of adjuvant chemotherapy and radiotherapy after operation in patients with mucoepidermoid carcinoma of parotid gland,and to screen the indicators ralated to the prognosis of tumor.Methods Eighty patients with mucoepidermoid carcinoma of parotid gland in First People′Hospital of Yibin of Sichuan Province from January 2005 to December 2009 were analysed retrospectively in our research.We studied the survival of patients who were treated wtih simple operation(30 cases)or postoperative adjuvant therapy(50 cases).Then we further analyzed the relationships between the prognosis of the patients and some variables (age,gender,smoking,alcohol drinking,lymph node metastasis,distant organ metastasis,treat-ment method,differentiation degree and T grading).Results Kaplan-Meier survival curves showed that patients with postoperative adjuvant therapy had longer PFS and OS than those without adjuvant therapy (94.4 months vs 69.3 months;114.9 months vs 96.7 months),with statistical significance (χ2 =11 .246,P =0.001 ;χ2 =15.803,P =0.001 ).COX univariate analysis showed that gender (χ2 =22.346,P =0.000),smoking (χ2 =7.891 ,P =0.041 ),lymph node metastasis (χ2 =12.371 ,P =0.005),distant organ metastasis (χ2 =9.81 3, P =0.002),treatment method (χ2 =25.261 ,P =0.000),differentiation degree (χ2 =4.361 ,P =0.006)and T grading (χ2 =5.336,P =0.01 4)were related to the PFS of patients.COX multivariate analysis showed that lymph node metastasis (χ2 =11 .003,RR =2.827,95%CI:1 .965-3.851 ,P =0.011 ),distant organ metastasis (χ2 =7.611 ,RR =0.472,95%CI:0.240-0.775,P =0.016),treatment method (χ2 =24.542,RR =5.390, 95%CI:3.585-9.602,P =0.000),degree of differentiation (χ2 =3.221 ,RR =2.1 1 8,95%CI:1 .845-4.719, P =0.009)and T grading (χ2 =4.336,RR =0.804,95%CI:0.681 -0.916,P =0.024)were related to the PFS of patients.COX univariate analysis showed that smoking (χ2 =4.551 ,P =0.008),alcohol drinking (χ2 =11 .742,P =0.048),lymph node metastasis (χ2 =14.886,P =0.009),distant organ metastasis (χ2 =6.71 3, P =0.005),treatment method (χ2 =22.411 ,P =0.000),degree of differentiation (χ2 =8.1 16,P =0.012)and T grading (χ2 =14.443,P =0.035)were related to the OS of patients.COX multivariate analysis showed that lymph node metastasis (χ2 =11 .711 ,RR =2.985,95%CI:1 .521 -3.999,P =0.005),distant organ metastasis (χ2 =5.390,RR =0.400,95%CI:0.201 -0.793,P =0.009),treatment method (χ2 =19.327,RR =5.086, 95%CI:3.241 -8.006,P =0.000),degree of differentiation (χ2 =7.084,RR =2.301 ,95%CI:1 .908-4.503, P =0.001 )and T grading (χ2 =1 3.229,RR =0.561 ,95%CI:0.348-0.867,P =0.040)were related to the OS of patients.Conclusion Adjuvant radiation and chemotherapy can obviously prolong the PFS and OS for the patients with mucoepidermoid carcinoma of parotid gland.Lymph node metastasis,distant organ metastasis,treat-ment method,differentiation degree and T grading can greatly influence the prognosis of patients with mucoepider-moid carcinoma of parotid gland,which can be used as independent prognostic indicators for the patients with mucoepidermoid carcinoma of parotid gland.

MUCOEPIDERMOID TUMOR: A CASE REPORT

Glandular odontogenic cyst : Report of three cases

Glandular odontogenic cyst(GOC) is a rare cyst of odontogenic origin, first described in 1988 by Gardner et al. Three glandular odontogenic cysts are presented which were experienced in the Dept. of Oral and Maxillofacial surgery, Yonsei University. The clinical characteristics, radiologic and histopathologic features, and method of treatment are discussed. One occured in the anterior maxilla, others in the mandible body area. One in the anterior maxilla showed swelling and tenderness, others not. All the lesion presented radiographically unilocular radiolucent lesion. Histopathologically, those were lined by nonkeratinizing stratified squamous epithelium of varying thickness showing plaque-like or spherical thickening. Partially, eosinophilic cuboidal cells lined the intraepithelial microcysts. Also, ciliated cuboidal cells and mucinous cells were observed. The cysts were treated by enucleation.

Clinicopathological Analysis of Glomerulonephritis with Asymptomatic Urinary Abnormalities in Children

The mucoepidermoid carcinoma is a rare tumor in the lung. A case of bronchial mucoepidermoid carcinoma diagnosed by fine needle aspiration cytology is presented. The smear showed many intermediate cells with occasional mucus-secreting cells. Malignant squamous cells were not present. The cellular arrangement of intermediate cells was overlapping and grouped in ball-like fashion. These cytologic features are unique for diagnosis of this tumor.

Fine Needle Aspiration Cytology of Mucoepidermoid Carcinoma of the Lung: A Case Report / 대한세포병리학회지

The mucoepidermoid carcinoma is a rare tumor in the lung. A case of bronchial mucoepidermoid carcinoma diagnosed by fine needle aspiration cytology is presented. The smear showed many intermediate cells with occasional mucus-secreting cells. Malignant squamous cells were not present. The cellular arrangement of intermediate cells was overlapping and grouped in ball-like fashion. These cytologic features are unique for diagnosis of this tumor.